Amino -alcohol-phenols, amino- acid - phenols and

29.22 - Oxygen-function amino-compounds (+). - Amino-alcohols, other than those containin more than one kind of oxygen function, their ethers and esters; salts thereo : P 2922.1 1 - - Monoethanolarnine and its salts 2922.12 -- Diethanolamine and its salts 2922.13 - - Triethanolarnine and its salts 2922.14 - - Dextropropoxyphene (INN) and its salts 2922.19 - - Other - Amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof : 2922.2 1 2922.29 - - Arninohydroxynaphthalenesulphonic acids and their salts - - Other - Amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof : 2922.3 1 - - Ansfepramone (INN), methadone (INN) and nomethadone (INN); salts thereof 2922.39 - - Other - Amino-acids, other than those containing more than function, and their esters; salts thereof: 2922.41 one kind of oxygen - - Lysine and its esters; salts thereof 2922.42 - - Glutamic acid and its salts 2922.43 - - Anthranilic acid and its salts 2922.44 - - Tilidine (INN)and its salts Other 2922.49 -- 2922.50 - Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen fwlction The term "oxygen-function amino-compounds" means amino-compounds which contain, in addition to an amine function, one or more of the oxygen h c t i o n s defined in Note 4 to Chapter 29 (alcohol, ether, phenol, acetal, aldehyde, ketone, etc., hctions), as well as their or anic and inorganic acid esters. This heading therefore covers amino-corn ounds which are su stitution derivatives of amines containing oxygen h c t i o n s of headings 2g05 to 29.20, and esters and salts thereof. Diazotisable amines and their salts of this heading diluted to standard strengths for the production of azo-dyes are also included here. Organic dyes are excluded fi-om this heading (Chapter 32). (A) AMINO-ALCOHOLS, THEIR ETHERS AND ESTERS; SALTS THEREOF These compounds contain one or more alcohol hydroxyl groups and one or more amino groups bound to atoms of carbon. These compounds contain as oxygen functions on1 alcohols, their ethers or esters, or a combination of these funct~ons.Any oxygen function foun in a non-parent segment attached to a parent amino-alcohol is disregarded for classification purposes. B (I) Monoethanolamine (NH2(CH2CH20H)).Rather viscous, colourless liquid; used for the manufacture of pharmaceuhcal products, soap, etc. (2) Diethanolamine (NH CH2CH20H)2).Colourless crystals or pale liquid; used for absorbing acid gases, in tanning or softening leathers, and in organic synthesis. (3) Triethanolamine (N(CH2CH20H)3).Viscous liquid. A base used in the soap and emulsion industries, and for dressing and finishing fabrics. r (4) (2-Benzoylox 2-methylbutyl)dimethylammonium chloride. Crystalline white powder; used as a loca anaesthetic. (5) Meclofenoxate. (6) Arnolol. (7) Sarpogrelate. (8) Arylethanolamines. (9) Tetramethyl- and tetraethyldiaminobenzhydrol. (10) Aminoethyl nitrate. (1 1) Methyldiethanolamine. (B) AMINO-NAPHTHOLS AND OTHER AMINO-PHENOLS, THEIR ETHERS AND ESTERS; SALTS THEREOF These are phenolic compounds in which one or more hydrogen atoms have been replaced by an oup (-m2). These compounds contain as oxygen functions only phenol functions, their aminoet ers or esters, or a combination of these functions. Any oxygen function found in a nonparent segment attached to a parent amino-naphthol or other amino-phenol is disregarded for classification purposes. W. (I) Aminohydroxynaphthalenesulphonicacids, e.g., (a) 7-Amino-1-naphthol-3-sulphonicacid (gamma acid); @) 8-Amino-1-naphthol-3,6-disulphonic acid (H acid). (3) Amino-o-, m- and p-cresols. (4) Diaminophenols. The ethers of amino-phenols include (a) Anisidines. (b) Dianisidines (bianisidines). (c) Phenetidines. (d) Cresidines. (e) 5-Nitro-2-propoxyaniline(2-amino-4-nitrophenol n-propylether). Hydroxy derivatives of diphenylamine and their salts are also included here. (C) AMINO-ALDEHYDES, AMINO-KETONES AND AMINO-QUINONES; SALTS THEREOF These contain the amino-group associated with the aldehyde group (-CHO), the ketone group (>C=O) or the quinone group (see the Explanatory Note to heading 29.14), respectively. (1) Aminobenzaldehydes. (2) Tetramethyl- and tetraethyldiaminobenzophenones. (3) Amino- and diaminoanthraquinones. (4) Anthrimides. (D) AMINO-ACIDS AND THEIR ESTERS; SALTS THEREOF These corn ounds contain one or more carboxylic acid h c t i o n s and one or more arnine functions. gnhYdrides, halides, peroxides and peroxyacids of carboxylic acids are regarded as acid functions. These compounds contain as ox gen functions only acids, their esters or their anh drides, halides, peroxides and peroxyaci s or a combination of these functions. Any oxygen k c t i o n found in a non-parent segment attached to a parent amino-acid is disregarded for classification purposes. B The amino-acids classified under this heading with their esters, salts and substitution derivatives include : (1) Lgsine (diamino-n-hexanoic acid). Colourless crystals. A cleavage product of silk gum and o er proteins. (2) Glutamic acid. Cleavage product of proteins. Obtained from gluten. Crystals used in medicine or in food industries. (3) Glycine (aminoacetic acid; glycocoll) (H2NCH2COOH). Large, colourless, regularly shaped crystals. Used in organic synthesis, etc. (4) Sarcosine (CH3NHCH2COOH).Methyl derivative of glycine; crystallises in prisms. (5) Alanine (2-aminopropionic acid). Hard needles. (6) p-Alanine (3-aminopropionic acid). Crystalline. (7) Phenylalanine. (8) Valine (a-arninoisovaleric acid). Crystals. (9) Leucine (a-aminoisocaproic acid). Obtained by hydrolysis of proteins; white opalescent crystals. Isoleucine. (10) Aspartic acid. Crystalline. (1 1) o-Aminobenzoic acid (anthranilic acid). Obtained synthetically; used for the manufacture of synthetic indigo. Among its derivatives is methyl anthranilate. (12) rn-Aminobenzoic acid. (l3)p-Aminobenzoic acid. Used in the preparation of dyestuffs, artificial perfumes and anaesthetics; also in medicine for its vitarmn activity. Its derivatives include ethyl and butyl -aminobenzoates. Procaine hydrochloride (diethylaminoeth 1 p-amnobenzoate Rydrochloride), small colourless and odourless crystals, is a loca anaesthetic used by oculists and dentists. Y (14) Phenylglycine. (15) Lisadimate. (E) AMINO-ALCOHOL-PHENOLS, AMJNO-ACID-PHENOLS AND OTHER AMINO-COMPOUNDS WITH OXYGEN FUNCTION This part includes, inter alia : (I) Tyrosine (p-hydroxyphenylalanine). (2) Serine (a-amino-p-hydroxypropionicacid). A cleavage product of silk gum and other proteins. (3) Aminosalicylic acids, including 5-aminosalicylic acid and 4-aminosalicylic acid. Crystalline powders. 5-Aminosalicylic acid is used in inorganic synthesis (e.g., for the manufacture of azo- and sulphur-d es); the sodium salt of 4-aminosalicylic acid is used in medicine for treating pulmonary tu erculosis. (4) Medifoxamine (N,N-dimethyl-2,2-diphenoxyethylamine),an amine compound with acetal function. (5) Propoxycaine. Certain substances of this heading, which are regarded as narcotic drugs or as psychotropic substances under international instruments, are indicated in the list appearing at the end of Chapter 29.

Subheading Explanatory Note. Subheadings 2922.11 to 2922.50 For subheading classification p oses, ether or organic or inorganic acid ester knctions are regarded either as alcohol, phenol or acldzctions, depending on the pos~tionof the ox gen function in relation to the amine grou . In these cases, only those oxygen functions present in &at part of the molecule situated between tfe amine function and the oxygen atom of either the ether or the ester fimction should be taken into consideration. If the compound contains two or more ether or ester functions, the molecule is segmented for classification purposes at the oxygen atom of each ether or ester function, and the only oxygen h c t i o n s considered are those found in the same segment as an arnine function; a segment containing an amine function is referred to as a ''parent" segment. For example, in the compound 3-(2-aminoethoxy)pro ionic acid, the parent se ent is aminoethanol, and the carbox lic acid oup is disregarded for classifcation purposes; as an e er of an amino-alcohol, this compoukiis classi lable in subheading 2922.19. B t%" If the compound has two or more arnine functions linked to the same ether or ester function, it is classifiable m the subheading that is last in numerical order; that subheadin is determined by considering the ether or ester function as either an alcohol, phenol or acid function, in re ation to each amine function. 29.23- Quaternary ammonium salts and hydroxides; phosphoaminolipids,whether or not chemically defined. 2923.10 2923.20 2923.90 lecithins and other - Choline and its salts - Lecithins and other phosphoaminolipids - Other 1 2 3 qat%mafyorgapic ammonium salts contain one tetravalent nitrogen cation R R R RWwhere R ,R ,R and R may be the same or different alkyl or aryl radicals (methyl, ethyl, tolyl etc.). This cation may be associated with hydroxide ion (OH? to give a quaternary ammonium hydroxide of eneral formula &N OH - corresponding to its inorganic parent ammonium hydroxide NH, H. The residuary valence may, however, be filled by other anions (chloride, bromide, iodide, etc.) to give quaternary ammonium salts. The most important salts and substitution derivatives of quaternary ammonium bases are : (1) Choline, its salts and derivatives. A h drox ethyltrimethylammonium hydroxide found in the bile, in the brain, in eg yolk, an in a 1 fresh seeds. A compound from which other very important biological su stances are derived (e.g., acetylcholine, methylcholine). %- B Y (2) Lecithins and other phosphoaminolipids. These are the combination of oleic, palmitic and other fatty acids or anic nitrogen base such as choline. They are so uble in ethanol. Lecithins are contained in vegetable tissue. f Commercial lecithin, which is also included in this heading, is redominantly soya-bean lecithin and consists of a mixture of acetone-insoluble phos hati es (general1 60 to 70 % by weight), soya-bean oil, fatty acids and carbohydrates. 8ommerclal soya- ean lecithin comes m brownish to light-coloured, more or less viscous form or, if the soya-bean oil has been extracted with acetone, in yellowish granules. f K Ovolecithin is used in medicine. Commercial soya-bean lecithin is used as an e m u l s i p g , dis ersing, etc. agent in the food and animal feed industries, in paints, in the petro eum in ustry, etc. (3) Tetramethylammonium iodide ((CH,),NI). (4) Tetramethylammonium hydroxide ((CH,),NOH). (5) Tetramethylammonium formate (HCOON(CH3),), used in medicine . (6) Betaine, a quaternary intramolecular salt, and betaine hydrochloride, used, e.g., in medicine, cosmetics and animal feeding.